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KMID : 1190620050010010032
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Journal of the Korean Wound Care Society
2005 Volume.1 No. 1 p.32 ~ p.37
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Comparison of Polyurethane Foam Dressings on Inducing Wound Epithelialization
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Han Seung-Kyu
Kim Se-Hyun
Lee Byung-Il
Kim Woo-Kyung
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Abstract
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Polyurethane foam dressings are becoming widely used in partial and full thickness skin wounds since they are safe and convenient to patients and physicians. However, the influence of polyurethane foam dressings on epithelialization has not been fully determined yet. This study was designed to compare two internationally available polyurethane foams and three locally made polyurethane foams as to their effects on the epithelialization in vivo. Twentywhite rats were used. A 5 mm punch was employed to excise skin and subcutaneous tissue in a round fashion at six sites on the back area of 10 rats. After creating 6 open wounds, above mentioned 5 polyurethane foams and gauze dressings were applied. On the 5th day the lengths of the nonepithelialized area were measured under light microscope. In addition, partial thickness wounds were created using carbon dioxide laser at six sites on the back of the another 10 rats. Six dressings were applied on the wounds as same as above. On the 4th day the degree of the epithelialization was measured and compared. In full thickness wound study the best wound closing was also seen in chitin mixed Medifoam-N group. In partial thickness wound study the best epithelialization was seen in chitin mixed Medifoam-N and chitosan mixed Medifoam-N groups. These results demonstrated that polyurethane foam dressings influenced the epithelialization, and chitin mixed Medifoam-N showed the best result. (J Korean Wound Care Soc 2005;1:32-37)
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KEYWORD
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Polyurethane foam dressing, Epithelialization
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